Professor of Medicine, Harvard Medical School
Chief Scientific Officer, Dana-Farber Cancer Institute
Dr. Kevin Haigis has a long-standing interest in intestinal biology and gastrointestinal cancers. He received his Ph.D. from the University of Wisconsin – Madison where, as a student in the laboratory of Dr. William Dove, he studied the chromosomal mechanisms governing tumor initiation in the ApcMin model of intestinal tumorigenesis. He performed his post-doctoral work in the laboratory of Dr. Tyler Jacks at the Massachusetts Institute of Technology. There, he focused on the role of the Ras oncoproteins in colorectal cancer, exploring the functional differences among the RAS family members in colorectal cancer. He was a Robert Black Fellow of the Damon Runyon Cancer Research Foundation and received the Howard Temin Award K01 from the National Cancer Institute.
Dr. Haigis has been a member of the Harvard Medical School faculty since 2007. He is currently a Professor of Medicine at Harvard Medical School and the Chief Scientific Officer at the Dana-Farber Cancer Institute. His laboratory combines computational and informatic approaches with experimental approaches in genetically engineered mice and human models to study the relationship between RAS signaling, colorectal cancer, and inflammation.
RAS signaling, Genetic networks, Therapeutic responses
M.H. Yang, S. Nickerson, E.T. Kim, C. Liot, G. Laurent, R. Spang, M.R. Philips, Y. Shan, D.E. Shaw, D. Bar-Sagi, M.C. Haigis, K.M. Haigis. Regulation of RAS oncogenicity by lysine acetylation. 2012. Proc. Natl Acad. Sci. USA 109: 10843-10848. PMID: 22711838, PMCID: PMC3390846
M.H. Yang, G. Laurent, A.S. Bause, R. Spang, N. German, M.C. Haigis, K.M. Haigis. 2013. HDAC6 and SIRT2 regulate the acetylation state and oncogenic activity of mutant K-RAS. Mol. Cancer. Res. 11: 1072-1077. PMID: 23723075, PMCID: PMC3778089
E.J. Poulin, A.K. Bera, J. Lu, Y-J. Lin, S.D. Strasser, J.A. Paulo, T.Q. Huang, C. Morales, W. Yan, J. Cook, J.A. Nowak, D.K. Brubaker, B.A. Joughin, C.W. Johnson, R.A. DeStefanis, P.C. Ghazi, S. Gondi, T.E. Wales, R.E. Iacob, L. Bogdanova, J.J. Gierut, Y. Li, J.R. Engen, P.A. Perez-Mancera, B.S. Braun, S.P. Gygi, D.A. Lauffenburger, K.D. Westover, K.M. Haigis. 2019. Tissue-specific oncogenic activity of K-RasA146T. Cancer Disc. 9: 738-755. PMID: 30952657, PMCID: PMC6548671
D.K. Brubaker, J.A. Paulo, S. Sheth, E.J. Poulin, O. Popow, B.A. Joughin, S.D. Strasser, A. Starchenko, S.P. Gygi, D.A. Lauffenburger, K.M. Haigis. 2019. Proteogenomic Network Analysis of Context-Specific KRAS Signaling In Mouse-to-Human Cross-Species Translation. Cell Systems 9: 258-270. PMID: 31521603. PMCID: PMC6816257.
F.M. Ferguson, B. Nabet, S. Raghavan, Y. Liu, A.L. Leggett, M. Kuljanin, R.L. Kalekar, A. Yang, S. He, J. Wang, R.W.S. Ng, R. Sulahian, L. Li, E.J. Poulin, L. Huang, J. Koren, N. Dieguez-Martinez, S. Espinosa, Z. Zeng, C.R. Corona, J.D. Vasta, R. Ohi, T. Sim, N.D. Kim, W. Harshbarger, J.M. Lizcano, M.B. Robers, S. Muthaswamy, C.Y. Lin, A.T. Look, K.M. Haigis, J.D. Mancias, B.M. Wolpin, A.J. Aguirre, W.C. Hahn, K.D. Westover, N.S. Gray. Discovery of a selective inhibitor of doublecortin like kinase 1. 2020. Nature Chemical Biology 16: 635-643. PMID: 32251410. PMCID: PMC7246176.